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UAB
Coagulation Service Individual Assay List
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| Primary
Name |
Antithrombin |
| Synonym |
Antithrombin
III |
| Synonym |
Heparin
Cofactor Activity |
| Contraction |
AT |
| Contraction |
AT
III |
| Contraction |
-- |
| UAB
Procedure Number |
1000760 |
| CPT
Code |
85300 |
| Specimen |
Collect
one (1) blue-stopper tube (3.2% sodium citrate), filled to specified
volume. Do not underfill or overfill.
|
| Specimen
Management |
Centrifuge
blue-stopper tube within 1 hour of collection, separate
plasma and test or quick-freeze at -70°C. |
| Specimen
Accepted |
Daily
including weekends |
| Times
Available |
All
times |
| Test
Performed |
*All
times
*When the antithrombin test is ordered as part of a thrombosis risk profile,
it is performed twice weekly. |
| Available
Stat? |
Yes |
| Description |
When
the functional AT level is consistently decreased, the patient may have
a congenital deficiency. Chronic AT deficiency confers a 10- to 20-fold
risk of venous thrombosis. Acquired AT deficiency occurs in prolonged
heparin therapy, disseminated intravascular coagulation, surgery, preeclampsia,
liver dysfunction, renal disease, and malignancies. Because the AT decreases
with heparin therapy, wait 10 days after ending treatment to collect specimen. |
| Reference
Interval |
78%
- 126% |
| Critical
Value |
-- |
| Therapeutic
Range |
-- |
| Follow-up
Test |
If
the functional AT assay indicates a congenital deficiency, the antithrombin
antigen assay may be used to distinguish qualitative from quantitative
disorders. |
| Associated
With |
Venous
thrombosis |
| Associated
With |
Disseminated
intravascular coagulation |
| Associated
With |
Liver
disease |
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