| Primary
Name |
Activated
protein C resistance |
| Synonym |
Screen
for factor V Leiden |
| Synonym |
-- |
| Contraction |
APC
resistance |
| Contraction |
APCR |
| Contraction |
-- |
| UAB
Procedure Number |
2500700 |
| CPT
Code |
85307 |
| Specimen |
*
Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified
volume. Do not underfill or overfill.
* If follow-up factor V Leiden mutation test is indicated, collect one
(1) lavender-stopper tube (EDTA) whole blood.
|
| Specimen
Management |
* Centrifuge
blue-stopper tube within 1 hour of collection, separate
plasma and test or quick-freeze at -70°C.
* The
lavender-stopper tube may be refrigerated up to 72 hours
before shipping. Ship overnight at ambient temperature
or on wet ice. |
| Specimen
Accepted |
Daily
including weekends |
| Times
Available |
0730
- 1600 |
| Test
Performed |
Twice
weekly |
| Available
Stat? |
Pathologist's
approval required. |
| Description |
APC
resistance is a thrombotic risk factor caused by the factor V Leiden mutation
that is present in 3 to 8% of Caucasians. Factor V Leiden mutation confers
a 2- to 8-fold increased risk of venous thrombosis. The APC resistance
assay is performed as a screen before ordering the confirmatory factor
V Leiden mutation assay. |
| Reference
Interval |
Ratio:
1.8 - 3. A pathology interpretation accompanies the report. |
| Critical
Value |
-- |
| Therapeutic
Range |
-- |
| Follow-up
Test |
Factor
V Leiden mutation is performed for confirmation if APCR is < 1.8. |
| Associated
With |
Venous
thrombosis |
