| Primary
Name |
Factor
VIII Inhibitor Titer |
| Synonym |
Bethesda
Titer for Factor VIII Inhibitor |
| Synonym |
-- |
| Contraction |
FVIII
Inhibitor |
| Contraction |
FVIII
Inh |
| Contraction |
-- |
| UAB
Procedure Number |
2500490 |
| CPT
Code |
85730,
85732, 85240, 85335 |
| Specimen |
Collect
one (1) blue-stopper tube (3.2% sodium citrate), filled to specified
volume. Do not underfill or overfill.
|
| Specimen
Management |
Centrifuge
blue-stopper tube within 1 hour of collection, separate
plasma and test or quick-freeze at -70°C. |
| Specimen
Accepted |
Daily
including weekends |
| Times
Available |
0730-1600;
deliver to lab by 1300 for same-day results |
| Test
Performed |
Monday-Friday. |
| Available
Stat? |
Pathologist's
approval required. |
| Description |
Factor
VIII inhibitors are IgG alloantibodies specific for therapeutic factor
VIII. Factor VIII inhibitors appear in 22 to 33% of severe hemophilia
patients. Inhibitors typically neutralize therapeutic factor VIII concentrates
making it necessary to provide patients with alternative therapy. Autoimmune
anti-factor VIII antibodies may arise in rare circumstances, causing acquired
hemophilia, with severe bleeding. |
| Reference
Interval |
None
detected |
| Critical
Value |
-- |
| Therapeutic
Range |
-- |
| Follow-up
Test |
Low-titer
and porcine factor VIII inhibitor assays available; contact the special
coagulation laboratory. |
| Associated
With |
Bleeding
disorders |
| Associated
With |
Coagulation
factor inhibitors |
