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UAB
Coagulation Service Individual Assay List
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| Primary
Name |
Protein
C Functional |
| Synonym |
Protein
C Activity |
| Synonym |
-- |
| Contraction |
PC |
| Contraction |
-- |
| Contraction |
-- |
| UAB
Procedure Number |
2500375 |
| CPT
Code |
85303 |
| Specimen |
Collect
one (1) blue-stopper tube (3.2% sodium citrate), filled to specified
volume. Do not underfill or overfill.
|
| Specimen
Management |
Centrifuge
blue-stopper tube within 1 hour of collection, separate
plasma and test or quick-freeze at -70°C. |
| Specimen
Accepted |
Daily
including weekends |
| Times
Available |
0730-1600 |
| Test
Performed |
Two
days a week |
| Available
Stat? |
-- |
| Description |
When
the functional PC level is consistently decreased, the patient may have
a congenital deficiency. Chronic PC deficiency confers a 6-fold risk of
venous thrombosis. Acquired PC deficiency occurs in disseminated intravascular
coagulation, surgery, preeclampsia, liver dysfunction, renal disease,
malignancies, and following any thrombotic episode. Protein C production
is decreased during Coumadin therapy. The protein C assay should be ordered
at least 10 days after a thrombotic event or after termination of Coumadin
therapy. |
| Reference
Interval |
70%-140% |
| Critical
Value |
-- |
| Therapeutic
Range |
-- |
| Follow-up
Test |
If
the functional PC assay indicates a deficiency, the protein C antigen
assay may be used to distinguish qualitative from quantitative disorders. |
| Associated
With |
Venous
thrombosis |
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